Data, narratives and tools produced by the Kits' sector/GeneDxChart/CSV
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Type,disease / drug tested,genes,patent holder and/or exclusive licensees,Companies,Number of US labs offering testing,license,key patents,other patents,product,typical testing cost,notes,report,links,References,,,, Dx,Breast & Ovarian Cancer,BRCA1,Myriad Genetics,Myriad Genetics,1,exclusive,"5753441, 6051379,",,BRACAnalysis,$3120 [2], ,"[1], [2]",http://www.myriad.com/products/bracanalysis.php,[1] Cook-Deegan et al. The dangers of diagnostic monopolies. Nature (2009) vol. 458 (7237) pp. 405-6,,,, ,,BRCA2,,,,,,,,,,,,[2] SACGHS. Appendix 1: Compendium of Case Studies on the Impact of Gene Patents and Licensing Practices on Access to Genetic Testing.  (2009) pp. 1-305,,,, Dx,colorectal cancer (HNPCC),MLH1,Oregon Health Sciences University + Dana Farber; Johns Hopkins ,"Baylor, Boston University, City of Hope, Harvard, Huntington, Mayo Clinic, University of Pennsylvania, Quest, Myriad, ",?,?,"5922855, 5591826 (protein), 5693470",,?,"Myriad, MLH1 + MSH2 + MSH6: $2950; see [2] pg A-12 for more prices", Cho M et al. Effect of patents and licenses on the provision of clinical genetic testing services. Journal of Molecular Diagnostics 2003 (February). 5(1):3-8. NB: FAP and HNPCC “patent enforcements” are more unlikely given non-exclusive licensing and multiple rights-holders.,"[1], [2]",,[3] Flockhart et al. Clinically available pharmacogenomics tests. Clinical pharmacology and therapeutics (2009) vol. 86 (1) pp. 109-13,,,, ,,MSH2,,,,,,,,,,,,,,,, ,,MSH6,,,,,,,,,,,,,,,, Dx,colorectal cancer (FAP),APC,,,,,,,,,,,,,,,, ,,MYH,,,,,,,,,,,,,,,, Dx,"Alzheimer’s, late-onset (LOAD, AD2)",APOE,"Duke university -> Athena Diagnostics (2 method patents for Dx alzheimer’s, don’t claim sequence, Bilski could destabilize; one claiming a kit) see [2]p B-6","Athena (St Louis Health Science Center offers cheaper APOE Dx for cardivascular disease; SunnyBrook Molecular Genetics Laboratory & McGill University Health Center provide APOE testing for AD for ~$100 canadian, [2]B-8)",1,exclusive,"5508167, 5716828, 6027896",,ADmark® ApoE Genotype Analysis & Interpretation (Symptomatic),"$475 ($365 for cardiovascular sequencing by St Louis Health Science Center, see note)","Cook-Deegan notes “penumbra effect” wrt Athena. Athena sublicensed APOE for DTC testing to Smart Genetics, but First Inventor on patent raised licensing complaints for ethical reasons ([2] B-16). APOE also is a marker for cardiovascular disease; testing for which does not infringe the methods patents, see [2]B-8; http://snpedia.com/index.php/Alzheimer's_disease. Also 2 testing labs in Canada, McGill and Sunnybrook both offer APOE testing for AD for $100 & $120 respectively [2]B-8.",,http://www.athenadiagnostics.com/content/test-catalog/find-test/service-detail/qid/35 ,,,,, ,"Alzheimer’s, early-onset (EOAD, AD3)",PSEN1,"Hospital for Sick Children, U Toronto -> Athena ",Athena,1,exclusive,6194153,"5986054, 6531586, 6248555(dropped),",ADmark® PS-1 DNA Sequencing Test,$1675 ([2]B-15),,,http://www.athenadiagnostics.com/content/test-catalog/find-test/service-detail/q/id/1261,,,,, ,"Alzheimer’s, early-onset (EOAD, AD4)",PSEN2,Hospital for Sick Children -> Athena,Athena,1,exclusive,5840540,6485911,ADmark® PS-2 DNA Sequencing Test,$1500?*,* http://www.alz.org/co/documents/2009_Symposium_handout_genetics.pdf,,http://www.athenadiagnostics.com/content/test-catalog/find-test/service-detail/q/id/1259,,,,, ,"Alzheimer’s, early-onset (EOAD, AD1)",APP,?,Athena,2,?,?,,ADmark® APP DNA Sequencing/Duplication Test; SignatureFISH,$1000?*,Signature genomics provides a FISH -based test for APP; only Athena does complete sequencing ,,http://www.athenadiagnostics.com/content/test-catalog/find-test/service-detail/q/id/1260 http://www.signaturegenomics.com/signaturefish.html,,,,, Dx,Haemochromatosis,HFE,Bio-Rad,,,,,,mDx Hereditary Hemochromatosis ASR kit; mDx Hereditary Hemochromatosis LLA ASR,,"Merz JF, Kriss AG, Leonard DGB, Cho MK. Op. cit. Examine licensing activities around HFE and impact on diagnostic prices",,,,,,, Dx,Cystic Fibrosis,CFTR,"University of Michigan, Hospital for Sick Children",,112,non-exclusive,5776677,"5876974, 7118911, 6984487, 6730777, 5407796",,,Johns Hopkins also has some key CFTR patents.,,,,,,, Dx,Long-QT syndrome,,PGxHealth; Bio-Reference Laboratories,,,,,,,,,"[1], [2]",,,,,, Dx,Spinocerebellar Ataxia,,Athena Diagnostics,,,exclusive,,,,Cook-Deegan notes “penumbra effect” wrt Athena,,"[1], [2]",,,,,, Dx,Tay-Sachs Disease,,,,,,,,,,,"[1], [2]",,,,,, Dx,Canavan Disease,,,,,,,,,,,"[1], [2]",,,,,, PGx,Coumadin (Warfarin),CYP2C9,,,,,,,Nanosphere Verigene Warfarin Metabolism Nucleic Acid Test,,,[3],http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2007/ucm108967.htm,,,,, PGx,Coumadin (Warfarin),VKORC1,,,,,,,,,,[3],,,,,, PGx,Sprycel (dasatinib) ,BCR-ABL,,,,,,,,,,[3],http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=11215,,,,,