Biotechnology - Genomic and Proteomics/IP Profile of Biggest for-profit companies in BGP/BGP Company Profiles - Data
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NIH
Celera
Amgen
Who
- 16,900 employees (2008 Corporate report)
- History of acquisition (http://www.amgen.com/about/acquisitions.html):
- 1994 - Synergen, Inc.
- 2000 - Kinetix Pharmaceuticals, Inc.
- 2002 - Immunex Corporation
- 2004 - Tularik, Inc.
- 2006 - Abgenix, Inc.
- 2006 - Avidia, Inc.
- 2007 - Ilypsa, Inc.
- 2007 - Alantos Pharmaceuticals Holdings, Inc.
- Subsidiaries (http://www.fundinguniverse.com/company-histories/Amgen-Inc-Company-History.html):
- Amgen Australia Pty Ltd.;
- Amgen N.V.; Amgen Canada Inc.;
- Amgen Greater China Ltd.;
- Amgen GmbH (Germany);
- Amgen S.A. (France);
- Amgen S.p.A. (Italy);
- Amgen K.K. (Japan);
- Amgen B.V. (Netherlands);
- Amgen-Biofarmaceutica (Portugal);
- Amgen S.A. (Spain);
- Amgen (Europe) AG (Switzerland);
- Kirin-Amgen, Inc. (Switzerland);
- Amgen Limited (U.K.);
- Amgen Sales Corporation (West Indies).
- Unlike many biotech companies, has been consistently profitable. Net profit in 2006 was US$2.9Billion (http://www.pharmaceutical-business-review.com/companyprofile.asp?guid=8632C7AC-1633-4198-8551-BB79570C668D)
- Managed to turn itself from a drug research company into a pharmaceutical company while maintaining steady sales - extremely rare in the industry (http://www.fundinguniverse.com/company-histories/Amgen-Inc-Company-History.html)
- Founded in 1980. By 1986 was starting to turn a profit, but did so not through drug development but through research partnerships with established pharma firms
- 1987, develop erythropoietin (EPO), which stimulates red blood cell creation. Sold the marketing rights to Johnson&Johnson
- Epogen proves to hugely popular - over $250m in sales in 1991 alone
- Between 1992 and 1996, Amgen's R&D budget goes from $182 million to $663 million
What
- ten approved drugs for 15 conditions, 23 agents are being tested earlier in the approval pipeline
- drugs include: Epogen, Aranesp, Enbrel, Kineret, Neulasta, Neupogen, Sensipar / Mimpara and Nplate
- As a side-result of this research, also publishes in academic journals (e.g. http://en.scientificcommons.org/40666678)
Where
- Thousand Oaks, CA
News
Commons-Based, Peer-Production, and Open Access News
- Amgen - marketing and R&D collaborations with (Powell pp. 72): ARRIS, Envirogen, Glycomex, Guilford, Interneuron, Regeneron, and Zynaxis. these companies develop the product that Amgen later produces and markets. Perhaps there are instances of commons-like sharing here. Further investigation needed
- Seems to be engaging in some instances of open-ended research with universities. e.g., collaboration with MIT's Whitehead institute (http://www.thefreelibrary.com/Axys+-+Amgen+Collaboration+Determines+the+X-Ray+Crystal+Structure+of...-a053047665)
- Further instances of academic collaboration here: http://www.brighamandwomens.org/Pressreleases/PressRelease.aspx?PageID=201
- The results of some scientific collaborations are being released into the commons: http://en.scientificcommons.org/40666678
- Says its committed to sharing clinical testing results as soon as possible (http://switch.atdmt.com/action/deicrm_N53107Policy_6)
Genentech
Who
- 11,000 employees ("Genentech," Wikipedia)
- Owned by Swiss pharma company Hoffman - La Roche ("Hoffman-La Rouche," http://en.wikipedia.org/wiki/Hoffmann-La_Roche)
What
- synthetic human insulin - their first famous product, many others produced using the Boyer-Cohen rDNA process
- along with data, has produced narratives: http://en.scientificcommons.org/genentech_inc
Where
- South San Francisco
News
Commons-Based, Peer-Production, and Open Access News
- Collaborated with Apple to create Open Source search engine for protein and DNA sequences (http://www.apple.com/ca/press/2002/02/genentech.html)
- Hoffman-La Rouche is engaging in academic collaboration to study the safety of InnoMed PredTox ("Hoffman-La Rouche," Wikipedia)
- In general, this seems to be a company that encourages its scientists to publish: http://www.gene.com/gene/research/researchvision.html
- Selected papers: http://en.scientificcommons.org/genentech_inc
- video of Genentechs Joe McCracken explaining incentives to publish (http://ecorner.stanford.edu/authorMaterialInfo.html?mid=1614)
- Has four-year post-doctoral program (http://www.gene.com/gene/research/researchvision.html)
- Also has additional clinical trial program (http://www.gene.com/gene/pipeline/fellowship/)
- supplies reagents for other research organizations' work: http://www.gene.com/gene/reagents-program/reagents-program.jsp
- Seems committed to engaging relevant stake-holders in public policy issues. Worked with the American Academy of Opthamology and the American Society of Retina Specialists to develop guidelines and answer questions about Avastin (http://www.gene.com/gene/news/press-releases/press_statements/ps_122007.html)
- Has a separate board to advise the company on issues of scientific research (http://www.gene.com/gene/research/resourceboard/)
- company gives researchers 20% free time to work on projects of their own
- VP for business development says the organization survives through science, not marketing.
- Collaboration with UC San Diego Scientists (http://www.universityofcalifornia.edu/news/article/19205)
- Funding for undergraduate research programs (http://www.genentechfoundation.com/about_focus.html)
- Providing infrastructure support for UCSF (http://news.ucsf.edu/releases/new-ucsf-mission-bay-campus-countrys-largest-biomedical-university-expansio/)
- Collaboration with Rockefeller University to look at therapeutic antibody potency (http://www.scienceblog.com/community/older/2000/D/200003674.html)
Genzyme
Gilead Sciences
Biogen Idec
Cephalon
MedImmune
Celgene
Abraxis BioScience
ImClone Systems
IP Profile of Biggest for-profit companies in BGP